Richard Tsien

Chair, Department of Physiology & Neuroscience at NYU Elaine A. & Kenneth G. Langone Medical Center

Richard Tsien

Richard Tsien

Chair, Department of Physiology & Neuroscience at NYU Elaine A. & Kenneth G. Langone Medical Center

Biography

Richard Tsien, D.Phil. Druckenmiller Professor of Neuroscience; Druckenmiller Professor of Neuroscience; Director Neuroscience Institute; Chair Dept of Physiology and Neuroscience Departments of Physiology and Neuroscience (Phys/Neuro) and Office of Science and Research (Neuroscience Institute-Chair) Education 1966 — Massachusetts Institute of Technology, Cambridge, MA, Electrical Engineering, Graduate Education 1970 — Oxford University, Oxford, England, D. Phil., Biophysics,, Graduate Education Research Summary We are studying how the location and identity of presynaptic calcium channels is regulated. Voltage-gated Ca2+ channels provide the critical link between the firing of a presynaptic nerve terminal and its release of neurotransmitter. The Ca2+ channels must be positioned very close to sites of vesicle fusion, and come in diverse forms with distinct activity-dependence, responsiveness to GABA, dopamine, acetylcholine and other neuromodulators, and susceptibility to neurological disorders such as migraine, ataxia or dystonia. Our working hypothesis involves molecular "slots" for particular types of channels. Slots regulate the mix of channel types and also help explain how defective channels might displace normal ones in genetically dominant disorders. Our lab is particularly interested in studying multiple modes of synaptic vesicle fusion. The opening of Ca2+ channels drives at least two distinct forms of fusion. In the classical mode, the vesicle membrane fully merges with and flattens into the presynaptic membrane (full collapse fusion). In a newly characterized mode, termed "kiss-and-run," the connection between the vesicle interior and the external medium lasts long enough to allow passage of neurotransmitter, but the connection is severed before the identity of the vesicle is lost. We study the dynamic properties and functional implications of both fusion modes by loading single synaptic vesicles with single photoluminescent reporter particles?quantum dots. Sharp distinctions between full collapse fusion and kiss-and-run are now in hand. Experiments are underway to monitor the same fusion event optically and electrophysiologically. One area of intense attention in our lab is the fundamental unit of cell-cell communication between brain neurons: quantal synaptic transmission. Presynaptic release of a packet of neurotransmitter, for example, glutamate, causes activation of postsynaptic receptors and a brief flow of current that promotes firing of the postsynaptic cell. We work on neuronal mechanisms that allow synapses to adapt to a sudden or long-lasting change in their level of activity. For example, blockade of impulses or of postsynaptic glutamate receptors causes a cascade of biochemical events that eventually leads to readjustment of critical molecular players on both sides of the synapse. We use state-of-the art methods to pin down the cell biology of changes in synaptic strength, of importance for adaptation of brain networks in learning and memory. Ongoing work in cultures of isolated neurons and brain slices. We study how synaptic transmission and depolarization cause changes in neuronal gene expression. Despite its importance, signaling from synapse or surface membrane to nucleus is only partly understood. One example of such signaling involves a local increase in Ca2+ concentration near a class of Ca2+ channels (L-type) different from those that trigger presynaptic transmitter release, subsequently leading to activation of an exemplar transcription factor, CREB, a regulator of transcription of many important neuronal genes. Our approach is to combine physiological approaches (how fast, how steeply voltage-dependent, how is signal transduced) and biochemical experiments using cDNA microarrays (which genes, in what context, what relationship to learning and memory). Publications Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission Alabi, AbdulRasheed A; Tsien, Richard W 2013 ;75:393-422, Annual review of physiology — id: 306382, year: 2013, vol: 75, page: 393, stat: Journal Article, AMPA receptor exchange underlies transient memory destabilization on retrieval Hong, Ingie; Kim, Jeongyeon; Kim, Jihye; Lee, Sukwon; Ko, Hyoung-Gon; Nader, Karim; Kaang, Bong-Kiun; Tsien, Richard W; Choi, Sukwoo 2013 May;110(20):8218-8223, Proceedings of the National Academy of Sciences of the United States of America — id: 421402, year: 2013, vol: 110, page: 8218, stat: Journal Article, pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity Li, Yulong; Tsien, Richard W 2012 ;15(7):1047-1053, Nature neuroscience — id: 173972, year: 2012, vol: 15, page: 1047, stat: Journal Article, Exploring the dominant role of Cav1 channels in signalling to the nucleus Ma, Huan; Cohen, Samuel; Li, Boxing; Tsien, Richard W 2012 ;33(1):203-209, Bioscience reports — id: 213912, year: 2012, vol: 33, page: 203, stat: Journal Article, Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity Mitra, Ananya; Mitra, Siddhartha S.; Tsien, Richard W. 2012 FEB;15(2):250-257, Nature neuroscience — id: 157623, year: 2012, vol: 15, page: 250, stat: Journal Article, Ca(V)1 and Ca(V)2 Channels Engage Distinct Modes of Ca(2+) Signaling to Control CREB-Dependent Gene Expression Wheeler, Damian G; Groth, Rachel D; Ma, Huan; Barrett, Curtis F; Owen, Scott F; Safa, Parsa; Tsien, Richard W 2012 May;149(5):1112-1124, Cell — id: 169566, year: 2012, vol: 149, page: 1112, stat: Journal Article, Mouse model of Timothy syndrome recapitulates triad of autistic traits Bader, Patrick L; Faizi, Mehrdad; Kim, Leo H; Owen, Scott F; Tadross, Michael R; Alfa, Ronald W; Bett, Glenna C L; Tsien, Richard W; Rasmusson, Randall L; Shamloo, Mehrdad 2011 Sep 13;108(37):15432-15437, Proceedings of the National Academy of Sciences of the United States of America — id: 138419, year: 2011, vol: 108, page: 15432, stat: Journal Article, Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer Faizi, Mehrdad; Bader, Patrick L; Tun, Christine; Encarnacion, Angelo; Kleschevnikov, Alexander; Belichenko, Pavel; Saw, Nay; Priestley, Matthew; Tsien, Richard W; Mobley, William C; Shamloo, Mehrdad 2011 Aug;43(2):397-413, Neurobiology of disease — id: 136716, year: 2011, vol: 43, page: 397, stat: Journal Article, Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons Groth, Rachel D; Lindskog, Maria; Thiagarajan, Tara C; Li, Li; Tsien, Richard W 2011 Jan 11;108(2):828-833, Proceedings of the National Academy of Sciences of the United States of America — id: 136719, year: 2011, vol: 108, page: 828, stat: Journal Article, Excitation-transcription coupling in sympathetic neurons and the molecular mechanism of its initiation Ma, Huan; Groth, Rachel D; Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W 2011 May;70(1):2-8, Neuroscience research — id: 136718, year: 2011, vol: 70, page: 2, stat: Journal Article, MicroRNA-mediated conversion of human fibroblasts to neurons Yoo, Andrew S; Sun, Alfred X; Li, Li; Shcheglovitov, Aleksandr; Portmann, Thomas; Li, Yulong; Lee-Messer, Chris; Dolmetsch, Ricardo E; Tsien, Richard W; Crabtree, Gerald R 2011 Aug 11;476(7359):228-231, Nature — id: 136717, year: 2011, vol: 476, page: 228, stat: Journal Article, Inhibitory role for GABA in autoimmune inflammation Bhat, Roopa; Axtell, Robert; Mitra, Ananya; Miranda, Melissa; Lock, Christopher; Tsien, Richard W; Steinman, Lawrence 2010 Feb 9;107(6):2580-2585, Proceedings of the National Academy of Sciences of the United States of America — id: 136723, year: 2010, vol: 107, page: 2580, stat: Journal Article, Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses Cao, Yu-Qing; Tsien, Richard W 2010 Mar 31;30(13):4536-4546, Journal of neuroscience — id: 136722, year: 2010, vol: 30, page: 4536, stat: Journal Article, Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity Lindskog, Maria; Li, Li; Groth, Rachel D; Poburko, Damon; Thiagarajan, Tara C; Han, Xue; Tsien, Richard W 2010 Dec 14;107(50):21806-21811, Proceedings of the National Academy of Sciences of the United States of America — id: 136720, year: 2010, vol: 107, page: 21806, stat: Journal Article, Inhibitory neurons hear themselves during development Owen, Scott F; Tsien, Richard W 2010 Apr 29;66(2):164-166, Neuron — id: 136721, year: 2010, vol: 66, page: 164, stat: Journal Article, Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B Espinosa, J Sebastian; Wheeler, Damian G; Tsien, Richard W; Luo, Liqun 2009 Apr 30;62(2):205-217, Neuron — id: 136724, year: 2009, vol: 62, page: 205, stat: Journal Article, The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles Zhang, Qi; Li, Yulong; Tsien, Richard W 2009 Mar 13;323(5920):1448-1453, Science — id: 136725, year: 2009, vol: 323, page: 1448, stat: Journal Article, The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels Barrett, Curtis F; Tsien, Richard W 2008 Feb 12;105(6):2157-2162, Proceedings of the National Academy of Sciences of the United States of America — id: 136731, year: 2008, vol: 105, page: 2157, stat: Journal Article, A role for retinoic acid in homeostatic plasticity Groth, Rachel D; Tsien, Richard W 2008 Oct 23;60(2):192-194, Neuron — id: 136727, year: 2008, vol: 60, page: 192, stat: Journal Article, Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation Kim, Jimok; Tsien, Richard W 2008 Jun 26;58(6):925-937, Neuron — id: 136729, year: 2008, vol: 58, page: 925, stat: Journal Article, Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo Liao, Yaping Joyce; Safa, Parsa; Chen, Yi-Ren; Sobel, Raymond A; Boyden, Edward S; Tsien, Richard W 2008 Feb 19;105(7):2705-2710, Proceedings of the National Academy of Sciences of the United States of America — id: 136730, year: 2008, vol: 105, page: 2705, stat: Journal Article, Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels Watase, Kei; Barrett, Curtis F; Miyazaki, Taisuke; Ishiguro, Taro; Ishikawa, Kinya; Hu, Yuanxin; Unno, Toshinori; Sun, Yaling; Kasai, Sayumi; Watanabe, Masahiko; Gomez, Christopher M; Mizusawa, Hidehiro; Tsien, Richard W; Zoghbi, Huda Y 2008 Aug 19;105(33):11987-11992, Proceedings of the National Academy of Sciences of the United States of America — id: 136728, year: 2008, vol: 105, page: 11987, stat: Journal Article, CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling Wheeler, Damian G; Barrett, Curtis F; Groth, Rachel D; Safa, Parsa; Tsien, Richard W 2008 Dec 1;183(5):849-863, Journal of cell biology — id: 136726, year: 2008, vol: 183, page: 849, stat: Journal Article, The sequence of events that underlie quantal transmission at central glutamatergic synapses Lisman, John E; Raghavachari, Sridhar; Tsien, Richard W 2007 Aug;8(8):597-609, Nature reviews. Neuroscience — id: 136733, year: 2007, vol: 8, page: 597, stat: Journal Article, Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes Shcherbakova, Olga G; Hurt, Carl M; Xiang, Yang; Dell'Acqua, Mark L; Zhang, Qi; Tsien, Richard W; Kobilka, Brian K 2007 Feb 12;176(4):521-533, Journal of cell biology — id: 136735, year: 2007, vol: 176, page: 521, stat: Journal Article, LTP and adaptation to inactivity: overlapping mechanisms and implications for metaplasticity Thiagarajan, Tara C; Lindskog, Maria; Malgaroli, Antonio; Tsien, Richard W 2007 Jan;52(1):156-175, Neuropharmacology — id: 136736, year: 2007, vol: 52, page: 156, stat: Journal Article, Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator Tour, Oded; Adams, Stephen R; Kerr, Rex A; Meijer, Rene M; Sejnowski, Terrence J; Tsien, Richard W; Tsien, Roger Y 2007 Jul;3(7):423-431, Nature Chemical Biology — id: 136734, year: 2007, vol: 3, page: 423, stat: Journal Article, Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles Zhang, Qi; Cao, Yu-Qing; Tsien, Richard W 2007 Nov 6;104(45):17843-17848, Proceedings of the National Academy of Sciences of the United States of America — id: 136732, year: 2007, vol: 104, page: 17843, stat: Journal Article, Selective engagement of plasticity mechanisms for motor memory storage Boyden, Edward S; Katoh, Akira; Pyle, Jason L; Chatila, Talal A; Tsien, Richard W; Raymond, Jennifer L 2006 Sep 21;51(6):823-834, Neuron — id: 136737, year: 2006, vol: 51, page: 823, stat: Journal Article, Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion Harata, Nobutoshi C; Aravanis, Alexander M; Tsien, Richard W 2006 Jun;97(6):1546-1570, Journal of neurochemistry — id: 136739, year: 2006, vol: 97, page: 1546, stat: Journal Article, Frequency-dependent kinetics and prevalence of kiss-and-run and reuse at hippocampal synapses studied with novel quenching methods Harata, Nobutoshi C; Choi, Sukwoo; Pyle, Jason L; Aravanis, Alexander M; Tsien, Richard W 2006 Jan 19;49(2):243-256, Neuron — id: 136740, year: 2006, vol: 49, page: 243, stat: Journal Article, L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W 2006 Jul;51(1):27-36, Neuropharmacology — id: 136738, year: 2006, vol: 51, page: 27, stat: Journal Article, Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel Barrett, Curtis F; Cao, Yu-Qing; Tsien, Richard W 2005 Jun 24;280(25):24064-24071, Journal of biological chemistry — id: 136743, year: 2005, vol: 280, page: 24064, stat: Journal Article, Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission Cao, Yu-Qing; Tsien, Richard W 2005 Feb 15;102(7):2590-2595, Proceedings of the National Academy of Sciences of the United States of America — id: 136744, year: 2005, vol: 102, page: 2590, stat: Journal Article, CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation Hudmon, Andy; Schulman, Howard; Kim, James; Maltez, Janet M; Tsien, Richard W; Pitt, Geoffrey S 2005 Nov 7;171(3):537-547, Journal of cell biology — id: 136741, year: 2005, vol: 171, page: 537, stat: Journal Article, Adaptation to synaptic inactivity in hippocampal neurons Thiagarajan, Tara C; Lindskog, Maria; Tsien, Richard W 2005 Sep 1;47(5):725-737, Neuron — id: 136742, year: 2005, vol: 47, page: 725, stat: Journal Article, Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy Cao, Yu-Qing; Piedras-Renteria, Erika S; Smith, Geoffrey B; Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W 2004 Aug 5;43(3):387-400, Neuron — id: 136745, year: 2004, vol: 43, page: 387, stat: Journal Article, Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W 2004 Jan 27;101(4):1063-1068, Proceedings of the National Academy of Sciences of the United States of America — id: 136747, year: 2004, vol: 101, page: 1063, stat: Journal Article, Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse Pagani, R; Song, M; McEnery, M; Qin, N; Tsien, R W; Toro, L; Stefani, E; Uchitel, O D 2004 ;123(1):75-85, Neuroscience — id: 136749, year: 2004, vol: 123, page: 75, stat: Journal Article, Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway Piedras-Renteria, Erika S; Pyle, Jason L; Diehn, Max; Glickfeld, Lindsey L; Harata, Nobutoshi C; Cao, Yuqing; Kavalali, Ege T; Brown, Patrick O; Tsien, Richard W 2004 Mar 9;101(10):3609-3614, Proceedings of the National Academy of Sciences of the United States of America — id: 136746, year: 2004, vol: 101, page: 3609, stat: Journal Article, Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium Smith, Stephen M; Bergsman, Jeremy B; Harata, Nobutoshi C; Scheller, Richard H; Tsien, Richard W 2004 Jan 22;41(2):243-256, Neuron — id: 136748, year: 2004, vol: 41, page: 243, stat: Journal Article, Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again Aravanis, A M; Pyle, J L; Harata, N C; Tsien, R W 2003 Nov;45(6):797-813, Neuropharmacology — id: 136750, year: 2003, vol: 45, page: 797, stat: Journal Article, Single synaptic vesicles fusing transiently and successively without loss of identity Aravanis, A M; Pyle, J L; Tsien, R W 2003 Jun 5;423(6940):643-647, Nature — id: 136751, year: 2003, vol: 423, page: 643, stat: Journal Article, Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation Choi, Sukwoo; Klingauf, Jurgen; Tsien, Richard W 2003 Apr 29;358(1432):695-705, Philosophical transactions of the Royal Society of London. Series B. Biological sciences — id: 136753, year: 2003, vol: 358, page: 695, stat: Journal Article, Signaling from synapse to nucleus: the logic behind the mechanisms Deisseroth, Karl; Mermelstein, Paul G; Xia, Houhui; Tsien, Richard W 2003 Jun;13(3):354-365, Current opinion in neurobiology — id: 136752, year: 2003, vol: 13, page: 354, stat: Journal Article, Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels Urbano, Francisco J; Piedras-Renteria, Erika S; Jun, Kisun; Shin, Hee-Sup; Uchitel, Osvaldo D; Tsien, Richard W 2003 Mar 18;100(6):3491-3496, Proceedings of the National Academy of Sciences of the United States of America — id: 136754, year: 2003, vol: 100, page: 3491, stat: Journal Article, Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels Cataldi, Mauro; Perez-Reyes, Edward; Tsien, Richard W 2002 Nov 29;277(48):45969-45976, Journal of biological chemistry — id: 136756, year: 2002, vol: 277, page: 45969, stat: Journal Article, Dynamic multiphosphorylation passwords for activity-dependent gene expression Deisseroth, Karl; Tsien, Richard W 2002 Apr 11;34(2):179-182, Neuron — id: 136757, year: 2002, vol: 34, page: 179, stat: Journal Article, alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength Thiagarajan, Tara C; Piedras-Renteria, Erika S; Tsien, Richard W 2002 Dec 19;36(6):1103-1114, Neuron — id: 136755, year: 2002, vol: 36, page: 1103, stat: Journal Article, Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling Harata, N; Pyle, J L; Aravanis, A M; Mozhayeva, M; Kavalali, E T; Tsien, R W 2001 Nov;24(11):637-643, Trends in neurosciences — id: 136760, year: 2001, vol: 24, page: 637, stat: Journal Article, Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion Harata, N; Ryan, T A; Smith, S J; Buchanan, J; Tsien, R W 2001 Oct 23;98(22):12748-12753, Proceedings of the National Academy of Sciences of the United States of America — id: 136761, year: 2001, vol: 98, page: 12748, stat: Journal Article, Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity Mermelstein, P G; Deisseroth, K; Dasgupta, N; Isaksen, A L; Tsien, R W 2001 Dec 18;98(26):15342-15347, Proceedings of the National Academy of Sciences of the United States of America — id: 136758, year: 2001, vol: 98, page: 15342, stat: Journal Article, Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6 Piedras-Renteria, E S; Watase, K; Harata, N; Zhuchenko, O; Zoghbi, H Y; Lee, C C; Tsien, R W 2001 Dec 1;21(23):9185-9193, Journal of neuroscience — id: 136759, year: 2001, vol: 21, page: 9185, stat: Journal Article, Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels Pitt, G S; Zuhlke, R D; Hudmon, A; Schulman, H; Reuter, H; Tsien, R W 2001 Aug 17;276(33):30794-30802, Journal of biological chemistry — id: 136762, year: 2001, vol: 276, page: 30794, stat: Journal Article, Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway Wu, G Y; Deisseroth, K; Tsien, R W 2001 Feb 27;98(5):2808-2813, Proceedings of the National Academy of Sciences of the United States of America — id: 136763, year: 2001, vol: 98, page: 2808, stat: Journal Article, Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology Wu, G Y; Deisseroth, K; Tsien, R W 2001 Feb;4(2):151-158, Nature neuroscience — id: 136764, year: 2001, vol: 4, page: 151, stat: Journal Article, Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1 Bergsman, J B; Tsien, R W 2000 Jun 15;20(12):4368-4378, Journal of neuroscience — id: 136768, year: 2000, vol: 20, page: 4368, stat: Journal Article, Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating Bezprozvanny, I; Zhong, P; Scheller, R H; Tsien, R W 2000 Dec 5;97(25):13943-13948, Proceedings of the National Academy of Sciences of the United States of America — id: 136765, year: 2000, vol: 97, page: 13943, stat: Journal Article, Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses' Choi, S; Klingauf, J; Tsien, R W 2000 Apr;3(4):330-336, Nature neuroscience — id: 136770, year: 2000, vol: 3, page: 330, stat: Journal Article, Syntaxin modulation of slow inactivation of N-type calcium channels Degtiar, V E; Scheller, R H; Tsien, R W 2000 Jun 15;20(12):4355-4367, Journal of neuroscience — id: 136769, year: 2000, vol: 20, page: 4355, stat: Journal Article, Nomenclature of voltage-gated calcium channels Ertel, E A; Campbell, K P; Harpold, M M; Hofmann, F; Mori, Y; Perez-Reyes, E; Schwartz, A; Snutch, T P; Tanabe, T; Birnbaumer, L; Tsien, R W; Catterall, W A 2000 Mar;25(3):533-535, Neuron — id: 136771, year: 2000, vol: 25, page: 533, stat: Journal Article, Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials Mermelstein, P G; Bito, H; Deisseroth, K; Tsien, R W 2000 Jan 1;20(1):266-273, Journal of neuroscience — id: 136772, year: 2000, vol: 20, page: 266, stat: Journal Article, Rapid reuse of readily releasable pool vesicles at hippocampal synapses Pyle, J L; Kavalali, E T; Piedras-Renteria, E S; Tsien, R W 2000 Oct;28(1):221-231, Neuron — id: 136766, year: 2000, vol: 28, page: 221, stat: Journal Article, Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit Zuhlke, R D; Pitt, G S; Tsien, R W; Reuter, H 2000 Jul 14;275(28):21121-21129, Journal of biological chemistry — id: 136767, year: 2000, vol: 275, page: 21121, stat: Journal Article, L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons Graef, I A; Mermelstein, P G; Stankunas, K; Neilson, J R; Deisseroth, K; Tsien, R W; Crabtree, G R 1999 Oct 14;401(6754):703-708, Nature — id: 136776, year: 1999, vol: 401, page: 703, stat: Journal Article, Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit Jun, K; Piedras-Renteria, E S; Smith, S M; Wheeler, D B; Lee, S B; Lee, T G; Chin, H; Adams, M E; Scheller, R H; Tsien, R W; Shin, H S 1999 Dec 21;96(26):15245-15250, Proceedings of the National Academy of Sciences of the United States of America — id: 136773, year: 1999, vol: 96, page: 15245, stat: Journal Article, Activity-dependent regulation of synaptic clustering in a hippocampal culture system Kavalali, E T; Klingauf, J; Tsien, R W 1999 Oct 26;96(22):12893-12900, Proceedings of the National Academy of Sciences of the United States of America — id: 136775, year: 1999, vol: 96, page: 12893, stat: Journal Article, Properties of fast endocytosis at hippocampal synapses Kavalali, E T; Klingauf, J; Tsien, R W 1999 Feb 28;354(1381):337-346, Philosophical transactions of the Royal Society of London. Series B. Biological sciences — id: 136779, year: 1999, vol: 354, page: 337, stat: Journal Article, Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices Liu, G; Choi, S; Tsien, R W 1999 Feb;22(2):395-409, Neuron — id: 136780, year: 1999, vol: 22, page: 395, stat: Journal Article, Visualization of synaptic activity in hippocampal slices with FM1-43 enabled by fluorescence quenching Pyle, J L; Kavalali, E T; Choi, S; Tsien, R W 1999 Dec;24(4):803-808, Neuron — id: 136774, year: 1999, vol: 24, page: 803, stat: Journal Article, Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits Smith, S M; Piedras-Rentera, E S; Namkung, Y; Shin, H S; Tsien, R W 1999 Apr 30;868:175-198, Annals of the New York Academy of Sciences — id: 136778, year: 1999, vol: 868, page: 175, stat: Journal Article, Calmodulin supports both inactivation and facilitation of L-type calcium channels Zuhlke, R D; Pitt, G S; Deisseroth, K; Tsien, R W; Reuter, H 1999 May 13;399(6732):159-162, Nature — id: 136777, year: 1999, vol: 399, page: 159, stat: Journal Article, Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons Deisseroth, K; Heist, E K; Tsien, R W 1998 Mar 12;392(6672):198-202, Nature — id: 136785, year: 1998, vol: 392, page: 198, stat: Journal Article, Kinetics and regulation of fast endocytosis at hippocampal synapses Klingauf, J; Kavalali, E T; Tsien, R W 1998 Aug 6;394(6693):581-585, Nature — id: 136783, year: 1998, vol: 394, page: 581, stat: Journal Article, Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons Namkung, Y; Smith, S M; Lee, S B; Skrypnyk, N V; Kim, H L; Chin, H; Scheller, R H; Tsien, R W; Shin, H S 1998 Sep 29;95(20):12010-12015, Proceedings of the National Academy of Sciences of the United States of America — id: 136782, year: 1998, vol: 95, page: 12010, stat: Journal Article, Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas Newcomb, R; Szoke, B; Palma, A; Wang, G; Chen, X h; Hopkins, W; Cong, R; Miller, J; Urge, L; Tarczy-Hornoch, K; Loo, J A; Dooley, D J; Nadasdi, L; Tsien, R W; Lemos, J; Miljanich, G 1998 Nov 3;37(44):15353-15362, Biochemistry — id: 136781, year: 1998, vol: 37, page: 15353, stat: Journal Article, Antisense oligonucleotides against alpha1E reduce R-type calcium currents in cerebellar granule cells Piedras-Renteria, E S; Tsien, R W 1998 Jun 23;95(13):7760-7765, Proceedings of the National Academy of Sciences of the United States of America — id: 136784, year: 1998, vol: 95, page: 7760, stat: Journal Article, Molecular physiology. Key clockwork component cloned Tsien, R W 1998 Feb 26;391(6670):'198'-'202', Nature — id: 136786, year: 1998, vol: 391, page: '198', stat: Journal Article, Ca2+-dependent regulation in neuronal gene expression Bito, H; Deisseroth, K; Tsien, R W 1997 Jun;7(3):419-429, Current opinion in neurobiology — id: 136789, year: 1997, vol: 7, page: 419, stat: Journal Article, Aspartate substitutions establish the concerted action of P-region glutamates in repeats I and III in forming the protonation site of L-type Ca2+ channels Chen, X H; Tsien, R W 1997 Nov 28;272(48):30002-30008, Journal of biological chemistry — id: 136787, year: 1997, vol: 272, page: 30002, stat: Journal Article, Dendritic Ca2+ channels characterized by recordings from isolated hippocampal dendritic segments Kavalali, E T; Zhuo, M; Bito, H; Tsien, R W 1997 Apr;18(4):651-663, Neuron — id: 136791, year: 1997, vol: 18, page: 651, stat: Journal Article, Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels Randall, A D; Tsien, R W 1997 Jul;36(7):879-893, Neuropharmacology — id: 136788, year: 1997, vol: 36, page: 879, stat: Journal Article, Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels Stocker, J W; Nadasdi, L; Aldrich, R W; Tsien, R W 1997 May 1;17(9):3002-3013, Journal of neuroscience — id: 136790, year: 1997, vol: 17, page: 3002, stat: Journal Article, CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression Bito, H; Deisseroth, K; Tsien, R W 1996 Dec 27;87(7):1203-1214, Cell — id: 136792, year: 1996, vol: 87, page: 1203, stat: Journal Article, Molecular basis of proton block of L-type Ca2+ channels Chen, X H; Bezprozvanny, I; Tsien, R W 1996 Nov;108(5):363-374, Journal of general physiology — id: 136793, year: 1996, vol: 108, page: 363, stat: Journal Article, Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity Deisseroth, K; Bito, H; Tsien, R W 1996 Jan;16(1):89-101, Neuron — id: 136796, year: 1996, vol: 16, page: 89, stat: Journal Article, Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus Wheeler, D B; Randall, A; Tsien, R W 1996 Apr 1;16(7):2226-2237, Journal of neuroscience — id: 136795, year: 1996, vol: 16, page: 2226, stat: Journal Article, Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W 1996 Nov;17(5):991-1003, Neuron — id: 136794, year: 1996, vol: 17, page: 991, stat: Journal Article, Functional impact of syntaxin on gating of N-type and Q-type calcium channels Bezprozvanny, I; Scheller, R H; Tsien, R W 1995 Dec 7;378(6557):623-626, Nature — id: 136797, year: 1995, vol: 378, page: 623, stat: Journal Article, Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967) Bezprozvanny, I; Tsien, R W 1995 Sep;48(3):540-549, Molecular pharmacology — id: 136801, year: 1995, vol: 48, page: 540, stat: Journal Article, Synaptic plasticity: A molecular mechanism for metaplasticity Deisseroth, K; Bito, H; Schulman, H; Tsien, R W 1995 Dec 1;5(12):1334-1338, Current biology. CB — id: 136798, year: 1995, vol: 5, page: 1334, stat: Journal Article, Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions Ellinor, P T; Yang, J; Sather, W A; Zhang, J F; Tsien, R W 1995 Nov;15(5):1121-1132, Neuron — id: 136799, year: 1995, vol: 15, page: 1121, stat: Journal Article, Properties of synaptic transmission at single hippocampal synaptic boutons Liu, G; Tsien, R W 1995 Jun 1;375(6530):404-408, Nature — id: 136803, year: 1995, vol: 375, page: 404, stat: Journal Article, Synaptic transmission at single visualized hippocampal boutons Liu, G; Tsien, R W 1995 Nov;34(11):1407-1421, Neuropharmacology — id: 136800, year: 1995, vol: 34, page: 1407, stat: Journal Article, Presynaptic component of long-term potentiation visualized at individual hippocampal synapses Malgaroli, A; Ting, A E; Wendland, B; Bergamaschi, A; Villa, A; Tsien, R W; Scheller, R H 1995 Jun 16;268(5217):1624-1628, Science — id: 136802, year: 1995, vol: 268, page: 1624, stat: Journal Article, Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons Randall, A; Tsien, R W 1995 Apr;15(4):2995-3012, Journal of neuroscience — id: 136804, year: 1995, vol: 15, page: 2995, stat: Journal Article, Reflections on Ca(2+)-channel diversity, 1988-1994 Tsien, R W; Lipscombe, D; Madison, D; Bley, K; Fox, A 1995 Feb;18(2):52-54, Trends in neurosciences — id: 136805, year: 1995, vol: 18, page: 52, stat: Journal Article, Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS Wheeler, D B; Randall, A; Sather, W A; Tsien, R W 1995 ;105:65-78, Progress in brain research — id: 136806, year: 1995, vol: 105, page: 65, stat: Journal Article, Nitric oxide synthase expression in single hippocampal neurons Chiang, L W; Schweizer, F E; Tsien, R W; Schulman, H 1994 Nov;27(1):183-188, Brain research. Molecular brain research — id: 136811, year: 1994, vol: 27, page: 183, stat: Journal Article, Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin Ellinor, P T; Zhang, J F; Horne, W A; Tsien, R W 1994 Nov 17;372(6503):272-275, Nature — id: 136808, year: 1994, vol: 372, page: 272, stat: Journal Article, An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i Friel, D D; Tsien, R W 1994 Jul;14(7):4007-4024, Journal of neuroscience — id: 136812, year: 1994, vol: 14, page: 4007, stat: Journal Article, Biophysical and pharmacological characterization of a class A calcium channel Sather, W A; Tanabe, T; Zhang, J F; Tsien, R W 1994 Dec 15;747:294-301, Annals of the New York Academy of Sciences — id: 136807, year: 1994, vol: 747, page: 294, stat: Journal Article, Structural basis of ion channel permeation and selectivity Sather, W A; Yang, J; Tsien, R W 1994 Jun;4(3):313-323, Current opinion in neurobiology — id: 136813, year: 1994, vol: 4, page: 313, stat: Journal Article, Existence of nitric oxide synthase in rat hippocampal pyramidal cells Wendland, B; Schweizer, F E; Ryan, T A; Nakane, M; Murad, F; Scheller, R H; Tsien, R W 1994 Mar 15;91(6):2151-2155, Proceedings of the National Academy of Sciences of the United States of America — id: 136815, year: 1994, vol: 91, page: 2151, stat: Journal Article, Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission Wheeler, D B; Randall, A; Tsien, R W 1994 Apr 1;264(5155):107-111, Science — id: 136814, year: 1994, vol: 264, page: 107, stat: Journal Article, Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system Wheeler, D B; Sather, W A; Randall, A; Tsien, R W 1994 ;29:155-171, Advances in second messenger & phosphoprotein research — id: 136816, year: 1994, vol: 29, page: 155, stat: Journal Article, Response Wheeler, D B; Tsien, R W; Randall, A 1994 Nov 4;266(5186):830-831, Science — id: 136809, year: 1994, vol: 266, page: 830, stat: Journal Article, Molecular determinants of voltage-dependent inactivation in calcium channels Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W 1994 Nov 3;372(6501):97-100, Nature — id: 136810, year: 1994, vol: 372, page: 97, stat: Journal Article, Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics Delcour, A H; Lipscombe, D; Tsien, R W 1993 Jan;13(1):181-194, Journal of neuroscience — id: 136825, year: 1993, vol: 13, page: 181, stat: Journal Article, Altered prevalence of gating modes in neurotransmitter inhibition of N-type calcium channels Delcour, A H; Tsien, R W 1993 Feb 12;259(5097):980-984, Science — id: 136823, year: 1993, vol: 259, page: 980, stat: Journal Article, Functional expression of a rapidly inactivating neuronal calcium channel Ellinor, P T; Zhang, J F; Randall, A D; Zhou, M; Schwarz, T L; Tsien, R W; Horne, W A 1993 Jun 3;363(6428):455-458, Nature — id: 136821, year: 1993, vol: 363, page: 455, stat: Journal Article, Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata Horne, W A; Ellinor, P T; Inman, I; Zhou, M; Tsien, R W; Schwarz, T L 1993 May 1;90(9):3787-3791, Proceedings of the National Academy of Sciences of the United States of America — id: 136822, year: 1993, vol: 90, page: 3787, stat: Journal Article, The kinetics of synaptic vesicle recycling measured at single presynaptic boutons Ryan, T A; Reuter, H; Wendland, B; Schweizer, F E; Tsien, R W; Smith, S J 1993 Oct;11(4):713-724, Neuron — id: 136819, year: 1993, vol: 11, page: 713, stat: Journal Article, Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits Sather, W A; Tanabe, T; Zhang, J F; Mori, Y; Adams, M E; Tsien, R W 1993 Aug;11(2):291-303, Neuron — id: 136820, year: 1993, vol: 11, page: 291, stat: Journal Article, Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels Yang, J; Ellinor, P T; Sather, W A; Zhang, J F; Tsien, R W 1993 Nov 11;366(6451):158-161, Nature — id: 136817, year: 1993, vol: 366, page: 158, stat: Journal Article, Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons Yang, J; Tsien, R W 1993 Feb;10(2):127-136, Neuron — id: 136824, year: 1993, vol: 10, page: 127, stat: Journal Article, Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons Zhang, J F; Randall, A D; Ellinor, P T; Horne, W A; Sather, W A; Tanabe, T; Schwarz, T L; Tsien, R W 1993 Nov;32(11):1075-1088, Neuropharmacology — id: 136818, year: 1993, vol: 32, page: 1075, stat: Journal Article, A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i Friel, D D; Tsien, R W 1992 May;450:217-246, Journal of physiology — id: 136828, year: 1992, vol: 450, page: 217, stat: Journal Article, Phase-dependent contributions from Ca2+ entry and Ca2+ release to caffeine-induced [Ca2+]i oscillations in bullfrog sympathetic neurons Friel, D D; Tsien, R W 1992 Jun;8(6):1109-1125, Neuron — id: 136826, year: 1992, vol: 8, page: 1109, stat: Journal Article, Persistent signalling and changes in presynaptic function in long-term potentiation Malgaroli, A; Malinow, R; Schulman, H; Tsien, R W 1992 ;164:176-91; discussion 192, CIBA Foundation symposium — id: 136829, year: 1992, vol: 164, page: 176, stat: Journal Article, Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons Malgaroli, A; Tsien, R W 1992 May 14;357(6374):134-139, Nature — id: 136827, year: 1992, vol: 357, page: 134, stat: Journal Article, Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels Cline, H T; Tsien, R W 1991 Feb;6(2):259-267, Neuron — id: 136832, year: 1991, vol: 6, page: 259, stat: Journal Article, omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor Horne, W A; Hawrot, E; Tsien, R W 1991 Jul 25;266(21):13719-13725, Journal of biological chemistry — id: 136831, year: 1991, vol: 266, page: 13719, stat: Journal Article, Long-term potentiation: postsynaptic activation of Ca(2+)-dependent protein kinases with subsequent presynaptic enhancement Malinow, R; Tsien, R W 1991 ;89:271-289, Progress in brain research — id: 136834, year: 1991, vol: 89, page: 271, stat: Journal Article, Molecular diversity of voltage-dependent Ca2+ channels Tsien, R W; Ellinor, P T; Horne, W A 1991 Sep;12(9):349-354, Trends in pharmacological science — id: 136830, year: 1991, vol: 12, page: 349, stat: Journal Article, Changes in presynaptic function during long-term potentiation Tsien, R W; Malinow, R 1991 ;635:208-220, Annals of the New York Academy of Sciences — id: 136833, year: 1991, vol: 635, page: 208, stat: Journal Article, Inhibition of Ca2+ and K+ channels in sympathetic neurons by neuropeptides and other ganglionic transmitters Bley, K R; Tsien, R W 1990 Mar;4(3):379-391, Neuron — id: 136836, year: 1990, vol: 4, page: 379, stat: Journal Article, Identifying and localizing protein kinases necessary for LTP Malinow, R; Tsien, R W 1990 ;268:301-305, Advances in experimental medicine & biology — id: 136837, year: 1990, vol: 268, page: 301, stat: Journal Article, Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices Malinow, R; Tsien, R W 1990 Jul 12;346(6280):177-180, Nature — id: 136835, year: 1990, vol: 346, page: 177, stat: Journal Article, Long-term potentiation: presynaptic enhancement following postsynaptic activation of Ca(++)-dependent protein kinases Tsien, R W; Malinow, R 1990 ;55:147-159, Cold Spring Harbor symposia on quantitative biology — id: 136840, year: 1990, vol: 55, page: 147, stat: Journal Article, Peptide inhibitors of PKC and CaMK block induction but not expression of long-term potentiation Tsien, R W; Schulman, H; Malinow, R 1990 ;24:101-107, Advances in second messenger & phosphoprotein research — id: 136838, year: 1990, vol: 24, page: 101, stat: Journal Article, Calcium channels, stores, and oscillations Tsien, R W; Tsien, R Y 1990 ;6:715-760, Annual review of cell biology — id: 136839, year: 1990, vol: 6, page: 715, stat: Journal Article, Voltage-gated calcium channels: direct observation of the anomalous mole fraction effect at the single-channel level Friel, D D; Tsien, R W 1989 Jul;86(13):5207-5211, Proceedings of the National Academy of Sciences of the United States of America — id: 136843, year: 1989, vol: 86, page: 5207, stat: Journal Article, The N-type Ca channel in frog sympathetic neurons and its role in alpha-adrenergic modulation of transmitter release Kongsamut, S; Lipscombe, D; Tsien, R W 1989 ;560:312-333, Annals of the New York Academy of Sciences — id: 136844, year: 1989, vol: 560, page: 312, stat: Journal Article, Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating Lipscombe, D; Kongsamut, S; Tsien, R W 1989 Aug 24;340(6235):639-642, Nature — id: 136842, year: 1989, vol: 340, page: 639, stat: Journal Article, Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP Malinow, R; Schulman, H; Tsien, R W 1989 Aug 25;245(4920):862-866, Science — id: 136841, year: 1989, vol: 245, page: 862, stat: Journal Article, Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes Rosenberg, R L; Isaacson, J S; Tsien, R W 1989 ;560:39-52, Annals of the New York Academy of Sciences — id: 136845, year: 1989, vol: 560, page: 39, stat: Journal Article, Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery Benham, C D; Tsien, R W 1988 Oct;404:767-784, Journal of physiology — id: 136847, year: 1988, vol: 404, page: 767, stat: Journal Article, Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons Hirning, L D; Fox, A P; McCleskey, E W; Olivera, B M; Thayer, S A; Miller, R J; Tsien, R W 1988 Jan 1;239(4835):57-61, Science — id: 136853, year: 1988, vol: 239, page: 57, stat: Journal Article, Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R W; Tsien, R Y 1988 Jul;1(5):355-365, Neuron — id: 136850, year: 1988, vol: 1, page: 355, stat: Journal Article, Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R Y; Tsien, R W 1988 Apr;85(7):2398-2402, Proceedings of the National Academy of Sciences of the United States of America — id: 136851, year: 1988, vol: 85, page: 2398, stat: Journal Article, Persistent protein kinase activity underlying long-term potentiation Malinow, R; Madison, D V; Tsien, R W 1988 Oct 27;335(6193):820-824, Nature — id: 136846, year: 1988, vol: 335, page: 820, stat: Journal Article, The effect of calcium channel antagonists on peripheral neurones Miller, R J; Ewald, D A; Fox, A P; Hirning, L D; McCleskey, E W; Perney, T M; Sturek, M; Thayer, S A; Tsien, R W; Walker, M W 1988 ;522:269-277, Annals of the New York Academy of Sciences — id: 136852, year: 1988, vol: 522, page: 269, stat: Journal Article, Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials Rosenberg, R L; Hess, P; Tsien, R W 1988 Jul;92(1):27-54, Journal of general physiology — id: 136849, year: 1988, vol: 92, page: 27, stat: Journal Article, Multiple types of neuronal calcium channels and their selective modulation Tsien, R W; Lipscombe, D; Madison, D V; Bley, K R; Fox, A P 1988 Oct;11(10):431-438, Trends in neurosciences — id: 136848, year: 1988, vol: 11, page: 431, stat: Journal Article, Two types of calcium channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings Benham, C D; Hess, P; Tsien, R W 1987 Oct;61(4 Pt 2):I10-I16, Circulation research — id: 136857, year: 1987, vol: 61, page: I10, stat: Journal Article, A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle Benham, C D; Tsien, R W 1987 Jul 16-22;328(6127):275-278, Nature — id: 136859, year: 1987, vol: 328, page: 275, stat: Journal Article, Calcium-permeable channels in vascular smooth muscle: voltage-activated, receptor-operated, and leak channels Benham, C D; Tsien, R W 1987 ;42:45-64, Society of General Physiologists series — id: 136863, year: 1987, vol: 42, page: 45, stat: Journal Article, Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones Fox, A P; Nowycky, M C; Tsien, R W 1987 Dec;394:149-172, Journal of physiology — id: 136856, year: 1987, vol: 394, page: 149, stat: Journal Article, Single-channel recordings of three types of calcium channels in chick sensory neurones Fox, A P; Nowycky, M C; Tsien, R W 1987 Dec;394:173-200, Journal of physiology — id: 136855, year: 1987, vol: 394, page: 173, stat: Journal Article, Isolated muscle cells as a physiological model Lieberman, M; Hauschka, S D; Hall, Z W; Eisenberg, B R; Horn, R; Walsh, J V; Tsien, R W; Jones, A W; Walker, J L; Poenie, M 1987 Sep;253(3 Pt 1):C349-C363, American journal of physiology — id: 136858, year: 1987, vol: 253, page: C349, stat: Journal Article, Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle McCleskey, E W; Fox, A P; Feldman, D H; Cruz, L J; Olivera, B M; Tsien, R W; Yoshikami, D 1987 Jun;84(12):4327-4331, Proceedings of the National Academy of Sciences of the United States of America — id: 136860, year: 1987, vol: 84, page: 4327, stat: Journal Article, Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons Strong, J A; Fox, A P; Tsien, R W; Kaczmarek, L K 1987 Feb 19-25;325(6106):714-717, Nature — id: 136861, year: 1987, vol: 325, page: 714, stat: Journal Article, Multiple types of calcium channel in excitable cells Tsien, R W; Fox, A P; Hess, P; McCleskey, E W; Nilius, B; Nowycky, M C; Rosenberg, R L 1987 ;41:167-187, Society of General Physiologists series — id: 136864, year: 1987, vol: 41, page: 167, stat: Journal Article, Calcium channels: mechanisms of selectivity, permeation, and block Tsien, R W; Hess, P; McCleskey, E W; Rosenberg, R L 1987 ;16:265-290, Annual review of biophysics & biophysical chemistry — id: 136862, year: 1987, vol: 16, page: 265, stat: Journal Article, Cardiac calcium currents at the level of single channels Tsien, R W; Nilius, B 1987 Dec 1;43(11-12):1169-1172, Experientia — id: 136854, year: 1987, vol: 43, page: 1169, stat: Journal Article, Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation Hess, P; Lansman, J B; Nilius, B; Tsien, R W 1986 ;8 Suppl 9:S11-S21, Journal of cardiovascular pharmacology — id: 136871, year: 1986, vol: 8 Suppl 9, page: S11, stat: Journal Article, Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells Hess, P; Lansman, J B; Tsien, R W 1986 Sep;88(3):293-319, Journal of general physiology — id: 136867, year: 1986, vol: 88, page: 293, stat: Journal Article, Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore Lansman, J B; Hess, P; Tsien, R W 1986 Sep;88(3):321-347, Journal of general physiology — id: 136866, year: 1986, vol: 88, page: 321, stat: Journal Article, Different types of calcium channels McCleskey, E W; Fox, A P; Feldman, D; Tsien, R W 1986 Sep;124:177-190, Journal of experimental biology — id: 136865, year: 1986, vol: 124, page: 177, stat: Journal Article, A novel type of cardiac calcium channel in ventricular cells Nilius, B; Hess, P; Lansman, J B; Tsien, R W 1986 ;45(1-2):S167-S170, Biomedica biochimica acta — id: 136870, year: 1986, vol: 45, page: S167, stat: Journal Article, Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating Rosenberg, R L; Hess, P; Reeves, J P; Smilowitz, H; Tsien, R W 1986 Mar 28;231(4745):1564-1566, Science — id: 136869, year: 1986, vol: 231, page: 1564, stat: Journal Article, Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists Tsien, R W; Bean, B P; Hess, P; Lansman, J B; Nilius, B; Nowycky, M C 1986 Jul;18(7):691-710, Journal of molecular & cellular cardiology — id: 136868, year: 1986, vol: 18, page: 691, stat: Journal Article, Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium Lee, K S; Marban, E; Tsien, R W 1985 Jul;364:395-411, Journal of physiology — id: 136874, year: 1985, vol: 364, page: 395, stat: Journal Article, A novel type of cardiac calcium channel in ventricular cells Nilius, B; Hess, P; Lansman, J B; Tsien, R W 1985 Aug 1-7;316(6027):443-446, Nature — id: 136872, year: 1985, vol: 316, page: 443, stat: Journal Article, Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644 Nowycky, M C; Fox, A P; Tsien, R W 1985 Apr;82(7):2178-2182, Proceedings of the National Academy of Sciences of the United States of America — id: 136875, year: 1985, vol: 82, page: 2178, stat: Journal Article, Three types of neuronal calcium channel with different calcium agonist sensitivity Nowycky, M C; Fox, A P; Tsien, R W 1985 Aug 1-7;316(6027):440-443, Nature — id: 136873, year: 1985, vol: 316, page: 440, stat: Journal Article, Beta-adrenergic modulation of calcium channels in frog ventricular heart cells Bean, B P; Nowycky, M C; Tsien, R W 1984 Jan 26-Feb 1;307(5949):371-375, Nature — id: 136880, year: 1984, vol: 307, page: 371, stat: Journal Article, Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers Cohen, C J; Bean, B P; Tsien, R W 1984 Jun;54(6):636-651, Circulation research — id: 136878, year: 1984, vol: 54, page: 636, stat: Journal Article, Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists Hess, P; Lansman, J B; Tsien, R W 1984 Oct 11-17;311(5986):538-544, Nature — id: 136876, year: 1984, vol: 311, page: 538, stat: Journal Article, Mechanism of ion permeation through calcium channels Hess, P; Tsien, R W 1984 May 31-Jun 6;309(5967):453-456, Nature — id: 136879, year: 1984, vol: 309, page: 453, stat: Journal Article, High selectivity of calcium channels in single dialysed heart cells of the guinea-pig Lee, K S; Tsien, R W 1984 Sep;354:253-272, Journal of physiology — id: 136877, year: 1984, vol: 354, page: 253, stat: Journal Article, Lidocaine block of cardiac sodium channels Bean, B P; Cohen, C J; Tsien, R W 1983 May;81(5):613-642, Journal of general physiology — id: 136881, year: 1983, vol: 81, page: 613, stat: Journal Article, Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells Lee, K S; Tsien, R W 1983 Apr 28;302(5911):790-794, Nature — id: 136882, year: 1983, vol: 302, page: 790, stat: Journal Article, Calcium channels in excitable cell membranes Tsien, R W 1983 ;45:341-358, Annual review of physiology — id: 136883, year: 1983, vol: 45, page: 341, stat: Journal Article, Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation Tsien, R W; Bean, B P; Hess, P; Nowycky, M 1983 ;48 Pt 1:201-212, Cold Spring Harbor symposia on quantitative biology — id: 136884, year: 1983, vol: 48 Pt 1, page: 201, stat: Journal Article, Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers Kass, R S; Tsien, R W 1982 Jun;38(3):259-269, Biophysical journal — id: 136889, year: 1982, vol: 38, page: 259, stat: Journal Article, Reversal of current through calcium channels in dialysed single heart cells Lee, K S; Tsien, R W 1982 Jun 10;297(5866):498-501, Nature — id: 136888, year: 1982, vol: 297, page: 498, stat: Journal Article, Effects of nystatin-mediated intracellular ion substitution on membrane currents in calf purkinje fibres Marban, E; Tsien, R W 1982 Aug;329:569-587, Journal of physiology — id: 136886, year: 1982, vol: 329, page: 569, stat: Journal Article, Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? Marban, E; Tsien, R W 1982 Aug;329:589-614, Journal of physiology — id: 136885, year: 1982, vol: 329, page: 589, stat: Journal Article, Properties of single calcium channels in cardiac cell culture Reuter, H; Stevens, C F; Tsien, R W; Yellen, G 1982 Jun 10;297(5866):501-504, Nature — id: 136887, year: 1982, vol: 297, page: 501, stat: Journal Article, Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating Cohen, C J; Bean, B P; Colatsky, T J; Tsien, R W 1981 Oct;78(4):383-411, Journal of general physiology — id: 136890, year: 1981, vol: 78, page: 383, stat: Journal Article, Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes Marban, E; Rink, T J; Tsien, R W; Tsien, R Y 1980 Aug 28;286(5776):845-850, Nature — id: 136891, year: 1980, vol: 286, page: 845, stat: Journal Article, Calcium-activated transient outward current in calf cardiac Purkinje fibres Siegelbaum, S A; Tsien, R W 1980 Feb;299:485-506, Journal of physiology — id: 136892, year: 1980, vol: 299, page: 485, stat: Journal Article, Tetrodotoxin block of cardiac sodium channels during repetitive or steady depolarizations in the rabbit [proceedings] Cohen, C J; Colatsky, T J; Tsien, R W 1979 Nov;296:70P-71P, Journal of physiology — id: 136893, year: 1979, vol: 296, page: 70P, stat: Journal Article, Sodium channels in rabbit cardiac Purkinje fibres Colatsky, J J; Tsien, R W 1979 Mar 15;278(5701):265-268, Nature — id: 136898, year: 1979, vol: 278, page: 265, stat: Journal Article, Electrical properties associated with wide intercellular clefts in rabbit Purkinje fibres Colatsky, T J; Tsien, R W 1979 May;290(2):227-252, Journal of physiology — id: 136896, year: 1979, vol: 290, page: 227, stat: Journal Article, Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured? Kass, R S; Siegelbaum, S A; Tsien, R W 1979 May;290(2):201-225, Journal of physiology — id: 136897, year: 1979, vol: 290, page: 201, stat: Journal Article, Ouabain increases the slow inward calcium current in ventricular muscle of the ferret [proceedings] Marban, E; Tsien, R W 1979 Jul;292:72P-73P, Journal of physiology — id: 136895, year: 1979, vol: 292, page: 72P, stat: Journal Article, Calcium-activated transient outward current in cardiac Purkinje fibres [proceedings] Siegelbaum, S A; Tsien, R W 1979 Feb;287:36P-37P, Journal of physiology — id: 136899, year: 1979, vol: 287, page: 36P, stat: Journal Article, Cellular and subcellular mechanisms of cardiac pacemaker oscillations Tsien, R W; Kass, R S; Weingart, R 1979 Aug;81:205-215, Journal of experimental biology — id: 136894, year: 1979, vol: 81, page: 205, stat: Journal Article, Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres Kass, R S; Lederer, W J; Tsien, R W; Weingart, R 1978 Aug;281:187-208, Journal of physiology — id: 136901, year: 1978, vol: 281, page: 187, stat: Journal Article, Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres Kass, R S; Tsien, R W; Weingart, R 1978 Aug;281:209-226, Journal of physiology — id: 136900, year: 1978, vol: 281, page: 209, stat: Journal Article, Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers Tsien, R W; Carpenter, D O 1978 Jun;37(8):2127-2131, Federation Proceedings (Federation of American Societies for Experimental Biology) — id: 136902, year: 1978, vol: 37, page: 2127, stat: Journal Article, Calcium ions and membrane current changes induced by digitals in cardiac Purkinje fibers Tsien, R W; Kass, R S; Weingart, R 1978 Apr 28;307:483-490, Annals of the New York Academy of Sciences — id: 136904, year: 1978, vol: 307, page: 483, stat: Journal Article, Is digitalis inotropy associated with enhanced slow inward calcium current? Weingart, R; Kass, R S; Tsien, R W 1978 Jun 1;273(5661):389-392, Nature — id: 136903, year: 1978, vol: 273, page: 389, stat: Journal Article, Role of intracellular calcium in the transient outward current of calf Purkinje fibres Siegelbaum, S A; Tsien, R W; Kass, R S 1977 Oct 13;269(5629):611-613, Nature — id: 136905, year: 1977, vol: 269, page: 611, stat: Journal Article, Cyclic AMP and contractile activity in heart Tsien, R W 1977 ;8:363-420, Advances in cyclic nucleotide research — id: 136906, year: 1977, vol: 8, page: 363, stat: Journal Article, Incomplete inactivation of the slow inward current in cardiac Purkinje fibres [proceedings] Kass, R S; Siegelbaum, S; Tsien, R W 1976 Dec;263(1):127P-128P, Journal of physiology — id: 136908, year: 1976, vol: 263, page: 127P, stat: Journal Article, Control of action potential duration by calcium ions in cardiac Purkinje fibers Kass, R S; Tsien, R W 1976 May;67(5):599-617, Journal of general physiology — id: 136910, year: 1976, vol: 67, page: 599, stat: Journal Article, Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres Lederer, W J; Tsien, R W 1976 Dec;263(2):73-100, Journal of physiology — id: 136907, year: 1976, vol: 263, page: 73, stat: Journal Article, Possible effects of hydrogen ions in ischemic myocardium Tsien, R W 1976 Mar;53(3 Suppl):I14-I16, Circulation — id: 136911, year: 1976, vol: 53, page: I14, stat: Journal Article, Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method Tsien, R W; Weingart, R 1976 Aug;260(1):117-141, Journal of physiology — id: 136909, year: 1976, vol: 260, page: 117, stat: Journal Article, Effects of acetylcholine on membrane currents in frog artrial muscle Giles, W; Tsien, R W 1975 Mar;246(2):64P-66P, Journal of physiology — id: 136915, year: 1975, vol: 246, page: 64P, stat: Journal Article, Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers Kass, R S; Tsien, R W 1975 Aug;66(2):169-192, Journal of general physiology — id: 136913, year: 1975, vol: 66, page: 169, stat: Journal Article, Proceedings: Transient inward current underlying strophanthidin's enhancement of pace-maker activity in Purkinje fibres Lederer, W J; Tsien, R W 1975 Jul;249(1):40P-41P, Journal of physiology — id: 136914, year: 1975, vol: 249, page: 40P, stat: Journal Article, Reconstruction of the electrical activity of cardiac Purkinje fibres McAllister, R E; Noble, D; Tsien, R W 1975 Sep;251(1):1-59, Journal of physiology — id: 136912, year: 1975, vol: 251, page: 1, stat: Journal Article, Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers Tsien, R W 1974 Sep;64(3):293-319, Journal of general physiology — id: 136917, year: 1974, vol: 64, page: 293, stat: Journal Article, Mode of action of chronotropic agents in cardiac Purkinje fibers. Does epinephrine act by directly modifying the external surface charge? Tsien, R W 1974 Sep;64(3):320-342, Journal of general physiology — id: 136918, year: 1974, vol: 64, page: 320, stat: Journal Article, Proceedings: Cyclic AMP: cell-to-cell movement and inotropic effect in ventricular muscle, studied by a cut-end method Tsien, R W; Weingart, R 1974 Oct;242(2):95P-96P, Journal of physiology — id: 136916, year: 1974, vol: 242, page: 95P, stat: Journal Article, Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres Tsien, R W 1973 Sep 26;245(143):120-122, Nature: new biology — id: 136920, year: 1973, vol: 245, page: 120, stat: Journal Article, Control of conductance in cardiac membrane permeability Tsien, R W 1973 Jun;11(3):204-210, Neurosciences research program bulletin — id: 136921, year: 1973, vol: 11, page: 204, stat: Journal Article, Proceedings: Does adrenaline act by directly modifying the external membrane surface charge of cardiac Purkinje fibres? Tsien, R W 1973 Oct;234(2):37P-39P, Journal of physiology — id: 136919, year: 1973, vol: 234, page: 37P, stat: Journal Article, Separation of the pace-maker and plateau components of delayed rectification in cardiac Purkinje fibres Hauswirth, O; Noble, D; Tsien, R W 1972 Aug;225(1):211-235, Journal of physiology — id: 136923, year: 1972, vol: 225, page: 211, stat: Journal Article, The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials Hausworth, O; Noble, D; Tsien, R W 1972 Apr;222(1):27-49, Journal of physiology — id: 136924, year: 1972, vol: 222, page: 27, stat: Journal Article, Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres Tsien, R W; Giles, W; Greengard, P 1972 Dec 6;240(101):181-183, Nature: new biology — id: 136922, year: 1972, vol: 240, page: 181, stat: Journal Article, Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials Hauswirth, O; McAllister, R E; Noble, D; Tsien, R W 1969 Oct;204(2):126P+-126P+, Journal of physiology — id: 136925, year: 1969, vol: 204, page: 126P+, stat: Journal Article, The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres Hauswirth, O; Noble, D; Tsien, R W 1969 Jan;200(1):255-265, Journal of physiology — id: 136926, year: 1969, vol: 200, page: 255, stat: Journal Article, Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres Noble, D; Tsien, R W 1969 Jan;200(1):205-231, Journal of physiology — id: 136928, year: 1969, vol: 200, page: 205, stat: Journal Article, Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current Noble, D; Tsien, R W 1969 Jan;200(1):233-254, Journal of physiology — id: 136927, year: 1969, vol: 200, page: 233, stat: Journal Article, Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers Hauswirth, O; Noble, D; Tsien, R W 1968 Nov 22;162(856):916-917, Science — id: 136929, year: 1968, vol: 162, page: 916, stat: Journal Article, Kinetics of slow component of potassium current in cardiac purkinje fibres Noble, D; Tsien, R W 1968 Jan;194(1):31P-32P, Journal of physiology — id: 136931, year: 1968, vol: 194, page: 31P, stat: Journal Article, The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres Noble, D; Tsien, R W 1968 Mar;195(1):185-214, Journal of physiology — id: 136930, year: 1968, vol: 195, page: 185, stat: Journal Article,

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Senior Vice President & General Counsel at NYU Langone Hospitals

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Ex Officio, Dean & CEO at New York University

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Director, Thoracic Surgery Research Program at NYU Elaine A. & Kenneth G. Langone Medical Center

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Chief of Service Anesthesia-Wh Department of Anesthesiology at NYU Elaine A. & Kenneth G. Langone Medical Center

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Chair, Radiation Oncology at NYU Elaine A. & Kenneth G. Langone Medical Center

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Senior Vice President/Vice Dean, Chief of Staff at NYU Langone Hospitals

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Vice Dean & Clinical Professor of Medicine, Division of Infectious Diseases at New York University - School of Medicine

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Chief of Hospital Operations at NYU Elaine A. & Kenneth G. Langone Medical Center

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Physician at New York Medical Associates PC

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Founder at Unique Features

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Richard Tsien
Chair, Department of Physiology & Neuroscience at NYU Elaine A. & Kenneth G. Langone Medical Center
Education
Dphil in Biophysics
Class of 1970

Oxford is a collegiate university, consisting of the central University and colleges. The central University is composed of academic departments and research centres, administrative departments, libraries and museums. The 38 colleges are self-governing and financially independent institutions, which are related to the central University in a federal system. There are also six permanent private halls, which were founded by different Christian denominations and which still retain their Christian character.

MA in Electrical Engineering
Class of 1966

Massachusetts Institute of Technology (MIT) is a private research university located in Cambridge, Massachusetts, United States. MIT has five schools and one college, containing a total of 32 academic departments, with a strong emphasis on scientific, engineering, and technological education and research. Founded in 1861 in response to the increasing industrialization of the United States, the institute used a polytechnic university model and stressed laboratory instruction. MIT was elected to the Association of American Universities in 1934.

Career History
Chair, Department of Physiology & Neuroscience
Current

NYU Langone Medical Center, a world-class, patient-centered, integrated, academic medical center, is one of the nation’s premier centers for excellence in clinical care, biomedical research and medical education. Located in the heart of Manhattan, NYU Langone is composed of four hospitals: Tisch Hospital, its flagship acute care facility; the Hospital for Joint Diseases, one of only five hospitals in the nation dedicated to orthopaedics and rheumatology; Hassenfeld Pediatric Center, a comprehensive pediatric hospital supporting a full array of children’s health services; and the Rusk Institute of Rehabilitation Medicine, the world’s first university-affiliated facility devoted entirely to rehabilitation medicine--plus NYU School of Medicine, which since 1841 has trained thousands of physicians and scientists who have helped to shape the course of medical history. The medical center’s tri-fold mission to serve, teach and discover is achieved 365 days a year through the seamless integration of a culture devoted to excellence in patient care, education and research.

Director
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Director
Current
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Director
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Political Donations
$2,600
2013

Minority Leader at Office of the Senate Minority Leader, Charles Schumer

$250
2012

Former President of United States

$375
2011

Former President of United States

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