Letisha Wyatt

Biomedical Research & Data Specialist & Assistant Professor, Neuroscience Graduate Program at Oregon Health & Science University

Letisha Wyatt

Letisha Wyatt

Biomedical Research & Data Specialist & Assistant Professor, Neuroscience Graduate Program at Oregon Health & Science University

Biography

Major Responsibilities

As the Basic Science Liaison:

* Cultivate and foster a sense of community and collaboration by acting as an interdisciplinary communicator.
* Continuous identification and evaluation of library materials and tools useful to the basic science faculty, residents, fellows, students, and staff.
* Keep informed on current issues in translational medicine and data science.

As the Research Data Management (RDM) librarian:
* Raise awareness and promote information service and literacy.
* Specialize in best practices for organizing and managing information throughout the data life cycle.
* Provide resource training, consultation, and expert support regarding data management for biomedical researchers at Oregon Health & Science University.
* Develop and implement new programs, curriculum, and services.

Education

* Ph.D., Molecular Pharmacology & Toxicology (2013), University of Southern California
* B.S., Neurobiology, Physiology, and Behavior (2005), University of California, Davis

Professional Experience

* Post-doctoral Fellow, Dr. Detlev Boison, R.S. Dow Neurobiology Laboratory, Legacy Research Institute (Portland, OR)
* Neuroanatomy Instructor, Dr. Rhonda McCoy, Sally Ride Science Camp, Education Unlimited, Stanford University (Palo Alto, CA)
* Graduate Research Assistant, Dr. Daryl L. Davies and Dr. Ronald L. Alkana, Alcohol and Brain Research Laboratory, University of Southern California (Los Angeles, CA)
* Graduate Students’ Advocate for Diversity Outreach, Dr. Sally Pratt and Dr. Richard Andalon, Graduate School Office, University of Southern California (Los Angeles, CA)
* Clinical Project Coordinator, Kelli Greene, Pacific Data Designs, Inc. (San Francisco, CA)
* Volunteer Research Assistant, Dr. Jeffrey Lansman, Cellular and Molecular Pharmacology Department, University of California, San Francisco (UCSF)

Publications & Presentations

Book Chapters

Wyatt LR (2015). Brain homeostasis and addiction. In: Boison, D and Masino SA, editors. Homeostatic Control of Brain Function. Oxford University Press.

Research Papers

Wyatt LR, Finn DA, Khoja S, Yardley MM, Asatryan L, Alkana RL, Davies, DL (2014). Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. Neurochemical Research 39(6): 1127-1139.Wyatt LR, Godar SC, Khoja S, Jakowec MW, Alkana RL, Bortolato M, Davies, DL (2013). Socio-communicative and sensorimotor impairments in male P2X4-deficient mice. Neuropsychopharmacology 38(10): 1993-2002.

Yardley MM, Wyatt L, Khoja S, Asatryan L, Finn DA, Alkana RL, Louie SG, Bortolato M, Davies DL (2012). Ivermectin reduces alcohol intake in mice. Neuropharmacology 63(2): 190-201.

Ostrovskaya O, Asatryan L, Wyatt L, Popova M, Li K, Peoples RW, Alkana RL, Davies DL (2011). Ethanol is a Fast Channel Inhibitor of P2X4 Receptors. Journal of Pharmacology and Experimental Therapeutics 337(1): 171-179.

Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL and Davies DL (2010). A Point Mutation in the Ectodomain-Transmembrane Domain Interfaces Eliminates Ethanol Response in P2X4 receptors. Journal of Neurochemistry 112(1): 307-317.

Posters for Scientific Meetings

Wyatt LR, Fine M, Minh C, Won M, Alkana RL, Jakowec MW, Davies DL. Development and use of lentiviral vector technology to investigate the role of accumbal P2X4 receptors in alcohol intake. Abstract for poster presentation, 36th Annual Research Society on Alcoholism Scientific Conference, June, 2013.

Asatryan L, Wyatt LR, Rodgers KE, Zlokovic BV, Davies DL, Alkana RL. Alcohol exposure alters expression of Purinergic P2X7Rs in brain pericytes. Abstract for poster presentation, 36th Annual Research Society on Alcoholism Scientific Conference, June, 2013.

Khoja S, Asatryan L, Wyatt LR, Alkana RL, Jakowec MW, Bortolato M, Davies DL. Knocking out P2X4 receptors changes glutamatergic receptor subunit expression in brain regions linked to alcohol behaviors. Abstract for poster presentation, 36th Annual Research Society on Alcoholism Scientific Conference, June, 2013.

Wyatt LR, Godar SC, Bortolato M, Fimreite V, Minh C, Alkana RL, Davies, DL. Deficiency of P2X4 receptors results in neurodevelopmental alterations in mice. Abstract for poster presentation, 41st Annual Society for Neuroscience Conference, October 2012.

Wyatt LR, Fimreite V, Minh C, Finn DA, Bortolato M, Alkana RL, Davies DL. P2X4 knockout mice display sex differences in alcohol intake and behavioral response. Abstract for poster presentation, 35th Annual Research Society on Alcoholism Scientific Conference, June, 2012.

Wyatt LR, Yardley M, Asatryan L, Azah A, Bortolato M, Finn DA, Alkana RL, Davies DL. Alcohol intake in male and female P2X4 knockout mice is significantly altered compared to littermate controls. Abstract for poster presentation, 34th Annual Research Society on Alcoholism Scientific Conference, June, 2011.

Yardley M, Wyatt LR, Asatryan L, Kuo D, Finn DA, Bortolato M, Louie SG, Petasis NA, Alkana RL, Davies DL. Ivermectin but not selamectin significantly reduces alcohol consumption in mice: Implications for novel therapeutic agents for alcohol use disorders. Abstract for poster presentation, 34th Annual Research Society on Alcoholism Scientific Conference, June, 2011.

Wyatt LR, Ostrovskaya O, Li K, Perkins D, Davies DL, Alkana RL. The structure of extracellular domain Loop 2 markedly affects ethanol sensitivity of GABA A receptors in a mammalian expression system. Abstract for poster presentation, 40th Annual Society for Neuroscience Conference, November 2010.

Yardley M, Wyatt LR, Asatryan L, Finn DA, Alkana RL, Davies DL. Ivermectin significantly reduces alcohol consumption in male and female C57BL/6 mice. Abstract for poster presentation, 40th Annual Society for Neuroscience Conference, November 2010.

Wyatt LR, Li K, Ostrovskaya O, Perkins D, Inamdar S, Asatryan L, Davies DL, Alkana RL. The structure of extracellular domain Loop 2 markedly affects ethanol sensitivity of a1 glycine receptors expressed in N2A cells. Abstract for poster presentation, 33rd Annual Research Society on Alcoholism Scientific Conference, June, 2010.

Asatryan L, Wyatt LR, Ostrovskaya O, Popova M, Woodward JJ, Alkana RL, Davies DL. Ethanol inhibits ATP-gated currents in hippocampal neurons following lentiviral-mediated expression of P2X4 receptors. Abstract for poster presentation, 39th Annual Society for Neuroscience Conference, October 2009.

Wyatt LR, Asatryan L, Woodward JJ, Alkana RL and Davies DL. Developing a Lentiviral Gene Delivery System to Investigate the Role of Purinergic P2X Receptors in Alcohol-Induced Behaviors in the CNS. Abstract for poster presentation, 32nd Annual Research Society on Alcoholism Scientific Conference, June, 2009.

Popova M, Asatryan L, Wyatt LR, Alkana RL and Davies DL. Physical-chemical properties of residues Asp331 and Met336 near the transmembrane domain 2 are important for ethanol action in purinergic P2X4 receptors. Abstract for poster presentation, 38th Annual Society for Neuroscience Conference, November 2008.

Popova M, Asatryan L, Wyatt LR, Alkana RL and Davies DL. Ectodomain residues Asp331 and Met336 near the transmembrane domain 2 of P2X4 receptors are important for the action of ethanol. Abstract for poster presentation, Purine and Pyrimidine Society Conference, Copenhagen, Denmark. June 29th - July 2nd 2008.

Grants and Awards

* Parkinson’s Disease Research Foundation Grant (2014-2016), R.S. Dow Neurobiology Laboratory, Legacy Research Institute Foundation
* Stroke Research Foundation Grant (2013-2016), R.S. Dow Neurobiology Laboratory, Legacy Research Institute Foundation Funds
* Outstanding Research Assistant Award (2011-2012), Department of Pharmacology & Pharmaceutical Sciences, University of Southern California
* Compact for Faculty Diversity, Institute on Teaching and Mentoring Scholarship (Fall 2011), Alliance for Graduate Education & the Professoriate, National S

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Faculty Emeritus at Oregon Health & Science University

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Professor at Oregon Health & Science University

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Professor at Oregon Health & Science University

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Former President at Society of American Gastrointestinal and Endoscopic Surgeons

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Vice President of Marketing & Communications at Oregon Health & Science University

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Founder at International Pachyonychia Congenita Consortium

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Affiliate Professor, Department of Physiology & Pharmacology at Oregon Health & Science University

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Professor-Hematology & Medical Oncology at Oregon Health & Science University

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Founding Scientist at Artielle ImmunoTherapeutics, Inc.

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Professor of Surgery at Oregon Health & Science University

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Letisha Wyatt
Biomedical Research & Data Specialist & Assistant Professor, Neuroscience Graduate Program at Oregon Health & Science University
Career History
Biomedical Research & Data Specialist & Assistant Professor, Neuroscience Graduate Program
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Oregon Health & Science University is dedicated to improving the health and quality of life for all Oregonians through excellence, innovation and leadership in health care, education and research. OHSU is the kind of place where the big news doesn't always involve sports, politics, fashion or even weather. The big news is always about health — health care, health education, health-related research. And various organizations and publications that rank American institutions, programs and faculty in a variety of categories have taken note. Nearly one million patient visits each year. Educating thousands of future health care providers. You get the picture. Immerse yourself in more facts and stats than you probably need about Portland's largest employer, Oregon's provider of care to every corner of the state, and one of the nation's top 28 biomedical research institutions. Oregon Health & Science University is the state’s only academic health center. It provides an uncommon array of services from providing the state’s most comprehensive health care, to educating the next generation of clinicians and biomedical researchers, to achieving breakthroughs and innovations.

Other Affiliations

Letisha Wyatt is affiliated with Oregon Health & Science University

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