James N. Topper

Managing Partner, Life Sciences Team at Frazier Healthcare Partners

James N. Topper

James N. Topper

Managing Partner, Life Sciences Team at Frazier Healthcare Partners

Career Highlights

Frazier Healthcare Partners
Arête Therapeutics, Inc.
Frazier Lifesciences Acquisition Corp.

RelSci Relationships


Number of Boards






Number of Awards


RelSci Relationships are individuals James N. Topper likely has professional access to. A relationship does not necessarily indicate a personal connection.

Co-Founder at Alcresta Therapeutics, Inc.

Relationship likelihood: Strong

Executive Chair at Atara Biotherapeutics, Inc.

Relationship likelihood: Strong

President, Chief Executive Officer & Director at Entasis Therapeutics Holdings, Inc.

Relationship likelihood: Strong

Co-Founder & Executive Chairman at Alpine Immune Sciences, Inc.

Relationship likelihood: Strong

Founder at Frazier Healthcare Partners

Relationship likelihood: Strong

President & Chief Executive Officer at AnaptysBio, Inc.

Relationship likelihood: Strong

Co-Founder at Third Rock Ventures LLC

Relationship likelihood: Strong

Managing Director at Sutter Hill Ventures LLC

Relationship likelihood: Strong

Global Head of Life Sciences at The Blackstone Group, Inc.

Relationship likelihood: Strong

Co-Founder at Mavupharma, Inc.

Relationship likelihood: Strong

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James N. Topper
Managing Partner, Life Sciences Team at Frazier Healthcare Partners

The University of Michigan (UM, U-M, UMich, or U of M), frequently referred to as simply Michigan, is a public research university located in Ann Arbor, Michigan, United States. It is the state's oldest university and the flagship campus of the University of Michigan. It is one of the original eight Public Ivy universities and is one of the founding members of the Association of American Universities. It has been ranked among the top five research universities in the US, and among the top 20 universities in the world. U-M also has satellite campuses in Flint and Dearborn.

Ph.D. in Biophysics

Stanford University, located between San Francisco and San Jose in the heart of California's Silicon Valley, is one of the world's leading teaching and research universities. Since its opening in 1891, Stanford has been dedicated to finding solutions to big challenges and to preparing students for leadership in a complex world.


A leader in the Biomedical Revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies. Our close proximity to the resources of the university—including the Schools of Business, Law, Humanities and Sciences and Engineering—our seamless relationship with our affiliated adult and children’s hospitals and our ongoing associations with the entrepreneurial endeavors of Silicon Valley make us uniquely positioned to accelerate the pace at which new knowledge is turned into tangible health benefits.

Career History
Vice President-Biology
1999 - 2003

COR Therapeutics, Inc.. The principal activities of the Company are the discovery, development and commercialization of novel pharmaceutical products to establish new standards of care for the treatment and prevention of severe cardiovascular diseases. Integrilin was the Company's first product taken from discovery to commercialization. A drug was approved to treat patients who undergo a procedure known as angioplasty to open blood vessels. This drug has also been approved to treat patients with intermittent chest pains known as unstable angina and patients suffering from a kind of Heart attack known as non-Q-wave myocardial infraction

Head, Cardiovascular Research & Development Franchise
2002 - 2003

Millennium Pharmaceuticals, Inc. operates as a biopharmaceutical company. Its products include Ninlaro and Velcade. The company was founded in 1993 and is headquartered in Cambridge, MA.

Managing Partner, Life Sciences Team
2003 - Current

Frazier Management invests in lower middle-market healthcare companies with $5-50 million in EBITDA and makes equity commitments ranging from $30-350 million. Investments take the form of buyouts, recapitalizations and corporate carveouts.

Boards & Committees
2018 - Current

Amunix, Inc. develops protein pharmaceuticals. It offers XTEN which is hydrophilic, unstructured, biodegradable polypeptides that impart a number of favorable properties upon the molecules to which they are attached. The company was founded by Volker Schellenberger and Willem Stemmer in 2006 and is headquartered in Mountain View, CA.

Independent Director
2018 - Current

Phathom Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company, which engages in the development and commercialization of novel treatments for gastrointestinal diseases. It focuses on its vonoprazan product, an oral small molecule potassium-competitive acid blocker. The company was founded by Tadataka Yamada, David Socks, Azmi Nabulsi, Aditya Kohli, and Roger Ulrich on January 9, 2018 and is headquartered in Florham Park, NJ.

Member, Board of Directors
2016 - Current

Alpine Immune Sciences, Inc. is a development-stage pharmaceutical company. The firm engages in the discovering of protein-based immunotherapies therapies targeting the immune synapse to treat cancer, autoimmune, and inflammatory disorders. It offers Immunotherapy, Immune Synapse, vIgD Platform Technology, and TIP Program. The company was founded in 2015 and is headquartered in Seattle, WA.

Member of the Advisory Board
Tenure Unconfirmed
Non-Profit Donations & Grants

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The American Society of Clinical Oncology is a non-profit organization founded in 1964 with the overarching goals of improving cancer care and prevention. More than 27,000 oncology practitioners belong to ASCO, representing all oncology disciplines and subspecialties. Members include physicians and health-care professionals in all levels of the practice of oncology.American Society of Clinical Oncology is the world’s leading professional organization representing physicians who treat people with cancer. ASCO’s members set the standard for patient care worldwide and lead the way in carrying out clinical research aimed at improving the prevention, diagnosis, and treatment of cancer. ASCO's efforts are also directed toward advocating for policies that provide access to high-quality care for all patients with cancer and at supporting the increased funding for clinical and translational research.

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AbbVie, Inc. purchases Mavupharma, Inc. from Frazier Healthcare Partners, Alpine Bioventures GP LLC

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Sorrento Therapeutics, Inc., SCILEX Pharmaceuticals, Inc. purchase Semnur Pharmaceuticals, Inc. from Frazier Healthcare Partners, Vivo Capital LLC, Canaan Management, Inc.

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OvaScience, Inc. purchases Millendo Therapeutics US, Inc. from New Enterprise Associates, Roche Ventures, 5AM Venture Management LLC, Ann Arbor Spark Business Accelerator, Altitude Funds LLC, Adams Street Partners LLC, Osage Partners LLC, Octalfa SAS, Longwood Fund Management LLC, Frazier Healthcare Partners, Renaissance Venture Capital Management, Inc.

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Portola Pharmaceuticals, Inc. engages in the development and commercialization of novel therapeutics in the areas of thrombosis, other hematologic disorders, and inflammation. It offers Andexxa and Bevyxxa medicines. The company was founded by Charles J. Homcy and David R. Philips on September 2, 2003 and is headquartered in South San Francisco, CA.

Public Holdings
Restricted data only for RelSci Professional users.
Awards & Honors
Rank #91
Forbes Magazine - The Midas List
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