Regeneron Pharmaceuticals, Inc.

In 1951, marking the 25th anniversary of the founding of Loomis, Sayles & Company, Robert H. Loomis sent a clear message to all clients. Click here to read. More than 60 years later, I echo the words of our founder when he said, "we wish to express our gratitude and appreciation to those who, through these difficult years, have helped us to the success we have enjoyed. We look to the future with humility but with confidence." The biggest difference in today's world is that our pace is faster and our playing field is larger. Given this scenario, our job at Loomis Sayles is to keep a laser-like “eye on the ball” particularly during times of uncertainty and volatility, where both risk and opportunity reside. My goal is to ensure that Loomis Sayles remains a broad-based, house of excellence trusted by our clients and recognized for our record of: Attracting and retaining exceptional investment professionals Providing caring, highly ethical and informative services to our clients Producing strong investment performance across our full stable of products The last five years have been a time of tremendous innovation for us. We have grabbed hold of opportunities presented by market upheaval to unearth some tremendous investments, build off our base and empower people to construct and test new capabilities. By integrating these with existing capabilities, (quantitative research, deeper risk analysis, greater macro-economic firepower, absolute return-oriented strategies and securitized capabilities), I believe we are a better investment firm than ever. On behalf of all Loomis Sayles employees, thank you for placing your confidence in us. From my personal vantage point, I am more confident than ever about the future of our company and the skills and passion of our people to deliver excellence in their work. We look forward to serving your investment needs as we face the ever-changing future together.

Renaissance Technologies LLC is an investment management company dedicated to producing superior returns for its clients and employees by adhering to mathematical and statistical methods.

Polen Capital employs a disciplined, bottom-up, concentrated US, Global and International equity investment strategies that focus on high quality growth investments. The Polen Focus Growth strategy invests in a concentrated portfolio of primarily large-cap US common stocks with sustainable competitive advantages. The Polen Global Growth strategy invests in a concentrated portfolio of outstanding US and international businesses with competitive advantages and the potential for sustained superior growth. It emphasizes sustainable earnings growth and focuses on companies with high returns on capital and double digit earnings growth. The Polen International Growth strategy applies the same philosophy as the Focus Growth and Global Growth portfolios, but invests exclusively in businesses domiciled outside of the US.