-UNIVERSITY OF HELSINKI: Skeletal disease found in Karelian Bear Dogs represents the first spontaneous animal model of human hypophosphatasia
A gene defect identified in Karelian Bear Dogs causes a severe bone disease. A gene test has been developed for diagnostic and breeding purposes.
A research group led by Professor Hannes Lohi at the University of Helsinki and Folkhalsan Research Center has uncovered a new skeletal disease in dogs. The disease was recognized in the Karelian Bear Dog breed, and associated with an autosomal recessive defect in the alkaline phosphatase gene, ALPL.
In humans, ALPL defects cause hypophosph...